Title : Low dose dinaciclib enhances doxorubicin-induced senescence in myeloma RPMI8226 cells by transformation of the p21 and p16 pathways.

Pub. Date : 2018 Nov

PMID : 30405800






1 Functional Relationships(s)
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1 Notably, the combination of dinaciclib and DOX inhibited cell growth and promoted senescence by transforming the suppressive effects of the ATM/Chk2/p53/p21 signaling pathway and enhancing the p16 signaling pathway. dinaciclib checkpoint kinase 2 Homo sapiens