Pub. Date : 2018 Oct 23
PMID : 30392338
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [Aspirin inhibits cell stemness of esophageal cancer by downregulation of chemokine CCL2]. | Aspirin | C-C motif chemokine ligand 2 | Homo sapiens |
| 2 | When chemokine CCL2 was knocked down, the levels of Nanog gene in M2+ shCCL2-KYSE450+ ASA group and M2+ shCCL2-KYSE450 group were decreased to 1.22+-0.11 and 1.17+-0.08, respectively, and there was no statistically significant difference between them (P=0.69). | Aspirin | C-C motif chemokine ligand 2 | Homo sapiens |
| 3 | Conclusions: Tumor-associated macrophages enhances the stemness of esophageal cancer cells, whereas aspirin attenuates the stemness by suppressing the expression of CCL2. | Aspirin | C-C motif chemokine ligand 2 | Homo sapiens |