Pub. Date : 2019 Feb 1
PMID : 30391783
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Gossypetin is a novel MKK3 and MKK6 inhibitor that suppresses esophageal cancer growth in vitro and in vivo. | gossypetin | mitogen-activated protein kinase kinase 3 | Homo sapiens |
| 2 | To identify the molecular target(s) of gossypetin, various signaling protein kinases were screened and results indicate that gossypetin strongly attenuates the MKK3/6-p38 signaling pathway by directly inhibiting MKK3 and MKK6 protein kinase activity in vitro. | gossypetin | mitogen-activated protein kinase kinase 3 | Homo sapiens |
| 3 | To identify the molecular target(s) of gossypetin, various signaling protein kinases were screened and results indicate that gossypetin strongly attenuates the MKK3/6-p38 signaling pathway by directly inhibiting MKK3 and MKK6 protein kinase activity in vitro. | gossypetin | mitogen-activated protein kinase kinase 3 | Homo sapiens |
| 4 | To identify the molecular target(s) of gossypetin, various signaling protein kinases were screened and results indicate that gossypetin strongly attenuates the MKK3/6-p38 signaling pathway by directly inhibiting MKK3 and MKK6 protein kinase activity in vitro. | gossypetin | mitogen-activated protein kinase kinase 3 | Homo sapiens |
| 5 | To identify the molecular target(s) of gossypetin, various signaling protein kinases were screened and results indicate that gossypetin strongly attenuates the MKK3/6-p38 signaling pathway by directly inhibiting MKK3 and MKK6 protein kinase activity in vitro. | gossypetin | mitogen-activated protein kinase kinase 3 | Homo sapiens |
| 6 | Additionally, the inhibition of cell growth by gossypetin is dependent on the expression of MKK3 and MKK6. | gossypetin | mitogen-activated protein kinase kinase 3 | Homo sapiens |
| 7 | Our findings suggest that gossypetin is an MKK3 and MKK6 inhibitor that could be useful for preventing or treating esophageal cancer. | gossypetin | mitogen-activated protein kinase kinase 3 | Homo sapiens |