Title : New benzimidazothiazole derivatives as anti-inflammatory, antitumor active agents: Synthesis, in-vitro and in-vivo screening and molecular modeling studies.

Pub. Date : 2019 Mar

PMID : 30391698






1 Functional Relationships(s)
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Protein Name
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1 For compound 25, it showed about 340 and 198 times more potent than celecoxib and naproxen respectively as COX-1 inhibitor (IC50 value 0.044 vs. 15.000 and 8.700 microM), and 10 and 115 times more potent than the same drugs as COX-2 inhibitor (IC50 value 4.52 vs. 40.00 and 520.00 nM). Celecoxib mitochondrially encoded cytochrome c oxidase II Homo sapiens