Title : Synthesis and evaluation of an AZD2461 [18F]PET probe in non-human primates reveals the PARP-1 inhibitor to be non-blood-brain barrier penetrant.

Pub. Date : 2019 Mar

PMID : 30390553






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Poly(ADP-ribose)polymerase-1 inhibitor (PARPi) AZD2461 was designed to be a weak P-glycoprotein (P-gp) analogue of FDA approved olaparib. olaparib ATP binding cassette subfamily B member 1 Homo sapiens
2 Poly(ADP-ribose)polymerase-1 inhibitor (PARPi) AZD2461 was designed to be a weak P-glycoprotein (P-gp) analogue of FDA approved olaparib. olaparib ATP binding cassette subfamily B member 1 Homo sapiens