Title : Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease.

Pub. Date : 2018 Nov 2

PMID : 30385548






1 Functional Relationships(s)
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1 Here, we found that pathologic alpha-syn activates poly(adenosine 5"-diphosphate-ribose) (PAR) polymerase-1 (PARP-1), and PAR generation accelerates the formation of pathologic alpha-syn, resulting in cell death via parthanatos. Adenosine poly(ADP-ribose) polymerase 1 Homo sapiens