Title : Classics in Chemical Neuroscience: Donepezil.

Pub. Date : 2019 Jan 16

PMID : 30372021






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1 This review is focused on donepezil and covers the background, synthetic routes, structure-activity relationships, binding interactions with acetylcholinesterase, pharmacokinetics and metabolism, efficacy, adverse effects, and historical importance of this leading therapeutic in the treatment of Alzheimer"s disease and true Classic in Chemical Neuroscience. Donepezil acetylcholinesterase (Cartwright blood group) Homo sapiens