Title : Interleukin-6 induces drug resistance in renal cell carcinoma.

Pub. Date : 2018 Dec 8

PMID : 30369518






1 Functional Relationships(s)
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1 And we found that 786-O RCC cells secrete high IL-6 levels after low dose stimulation with the TKIs sorafenib, sunitinib and pazopanib, inducing activation of AKT-mTOR pathway, NFkappaB, HIF-2alpha and VEGF expression. Sunitinib AKT serine/threonine kinase 1 Homo sapiens