Pub. Date : 2019 May
PMID : 30367494
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PGE2 -induced increase in COX-2 expression and, thereby, in transcriptional increase in HIF-1alpha expression was due to EGFR activation, leading to the activation of Phosphoinositide 3-kinase/Akt, Extracellular signal -regulated kinases 1/2, p38 and Mitogen- and stress-activated protein kinase-1 (PI3K/Akt, Erk1/2, p38 and MSK-1). | Dinoprostone | epidermal growth factor receptor | Homo sapiens |
| 2 | Collectively, the data suggest that EGFR-dependent COX-2 upregulation by a novel positive feedback loop triggered by iPGE2 underlies the intracrine pro-tumoral effects of PGE2 in PC3 cells. | Dinoprostone | epidermal growth factor receptor | Homo sapiens |