Title : Nintedanib-cyclodextrin complex to improve bio-activity and intestinal permeability.

Pub. Date : 2019 Jan 15

PMID : 30366544






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Cyclodextrin complex of nintedanib was prepared aiming for increased bio-activity and improved transport across intestinal membrane with reduced p-glycoprotein (p-gp) efflux. Cyclodextrins ATP binding cassette subfamily B member 1 Homo sapiens
2 Cyclodextrin complex of nintedanib was prepared aiming for increased bio-activity and improved transport across intestinal membrane with reduced p-glycoprotein (p-gp) efflux. Cyclodextrins ATP binding cassette subfamily B member 1 Homo sapiens
3 Interestingly, complexation has increased transport of nintedanib across intestinal membrane and reduced efflux ratio, suggesting the role of cyclodextrin complexation in modulating p-gp efflux. Cyclodextrins ATP binding cassette subfamily B member 1 Homo sapiens