Title : Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors.

Pub. Date : 2019 Jan 1

PMID : 30366255






1 Functional Relationships(s)
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1 Herein we envisaged the possibility of exploiting alkyl nitrates as precursors of alcohol-bearing dual inhibitors targeting acetylcholinesterase (AChE) and monoamine oxidase B (MAO B), key enzymes in neurodegenerative syndromes such as Alzheimer"s disease (AD), through biotransformation unmasking an alcoholic function upon nitric oxide (NO) release. Alcohols acetylcholinesterase (Cartwright blood group) Homo sapiens