Pub. Date : 2019 Mar
PMID : 30362574
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVES: The aim of this research was to assess regional difference in the intestinal absorption of ranitidine HCl as an indicator for the potential effect of P-glycoprotein (P-gp) efflux transporters. | Ranitidine | ATP-dependent translocase ABCB1 | Oryctolagus cuniculus |
| 2 | OBJECTIVES: The aim of this research was to assess regional difference in the intestinal absorption of ranitidine HCl as an indicator for the potential effect of P-glycoprotein (P-gp) efflux transporters. | Ranitidine | ATP-dependent translocase ABCB1 | Oryctolagus cuniculus |
| 3 | METHODS: In situ rabbit intestinal perfusion was used to investigate absorption of ranitidine HCl, a substrate for P-gp efflux from duodenum, jejunum, ileum and colon. | Ranitidine | ATP-dependent translocase ABCB1 | Oryctolagus cuniculus |
| 4 | CONCLUSIONS: The results indicate that P-gp transporters play a major role in determining regional difference in intestinal absorption of ranitidine HCl. | Ranitidine | ATP-dependent translocase ABCB1 | Oryctolagus cuniculus |