Title : Lacosamide for SCN2A-related intractable neonatal and infantile seizures.

Pub. Date : 2018 Oct 1

PMID : 30361185






2 Functional Relationships(s)
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1 Previous reports suggest that traditional sodium channel blockers (SCBs) such as phenytoin, carbamazepine, and lamotrigine have a beneficial effect on SCN2A-related neonatal seizures, as they counteract the gain-of-function effect of mutated Nav1.2 channels. Carbamazepine sodium voltage-gated channel alpha subunit 2 Homo sapiens
2 Previous reports suggest that traditional sodium channel blockers (SCBs) such as phenytoin, carbamazepine, and lamotrigine have a beneficial effect on SCN2A-related neonatal seizures, as they counteract the gain-of-function effect of mutated Nav1.2 channels. Carbamazepine sodium voltage-gated channel alpha subunit 2 Homo sapiens