Pub. Date : 2018 Nov 30
PMID : 30361093
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We demonstrated that expressions of HRD1 and Suppressor/Enhancer Lin12 1-like (SEL1L: a HRD1 stabilizer) increased in SH-SY5Y human neuroblastoma cells upon exposure to 6-hydroxydopamine (6-OHDA). | Oxidopamine | synoviolin 1 | Homo sapiens |
| 2 | We demonstrated that expressions of HRD1 and Suppressor/Enhancer Lin12 1-like (SEL1L: a HRD1 stabilizer) increased in SH-SY5Y human neuroblastoma cells upon exposure to 6-hydroxydopamine (6-OHDA). | Oxidopamine | synoviolin 1 | Homo sapiens |
| 3 | We demonstrated that expressions of HRD1 and Suppressor/Enhancer Lin12 1-like (SEL1L: a HRD1 stabilizer) increased in SH-SY5Y human neuroblastoma cells upon exposure to 6-hydroxydopamine (6-OHDA). | Oxidopamine | synoviolin 1 | Homo sapiens |
| 4 | We demonstrated that expressions of HRD1 and Suppressor/Enhancer Lin12 1-like (SEL1L: a HRD1 stabilizer) increased in SH-SY5Y human neuroblastoma cells upon exposure to 6-hydroxydopamine (6-OHDA). | Oxidopamine | synoviolin 1 | Homo sapiens |
| 5 | The 6-OHDA-induced cell death was suppressed in cells overexpressing wt-HRD1, whereas cell death was enhanced in cells with knockdown of HRD1 expression. | Oxidopamine | synoviolin 1 | Homo sapiens |
| 6 | These results suggest that HRD1 is a key molecule involved in 6-OHDA-induced cell death. | Oxidopamine | synoviolin 1 | Homo sapiens |
| 7 | As a result, 6-OHDA-induced cell death was enhanced in cells suppressing SEL1L expression, and this cell death was much more evident than that in cells with suppression of HRD1 expression. | Oxidopamine | synoviolin 1 | Homo sapiens |
| 8 | These findings strongly indicate that SEL1L is necessary for maintaining and stabilizing the amount of HRD1 protein, and stabilizing the amount of HRD1 protein through SEL1L may serve to protect against 6-OHDA-induced cell death. | Oxidopamine | synoviolin 1 | Homo sapiens |
| 9 | This intracellular transduction may suppress the enhancement of 6-OHDA-induced cell death caused by the loss of HRD1. | Oxidopamine | synoviolin 1 | Homo sapiens |