Pub. Date : 2018 Dec 5
PMID : 30355625
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | When photostimulation of genetically identified terminals is used to release only GABA, CB1R-dependent DSI persists for many minutes. | gamma-Aminobutyric Acid | cannabinoid receptor 1 (brain) | Mus musculus |
| 2 | These observations suggest that heterologous interactions between mGluRs and CB1Rs control the temporal window of DSI at GABA synapses, providing evidence for a powerful new way to affect functional circuit connectivity in the brain.SIGNIFICANCE STATEMENT Postsynaptic depolarization liberates endocannabinoids, resulting in a rapid and transient decrease in release probability at GABA synapses. | gamma-Aminobutyric Acid | cannabinoid receptor 1 (brain) | Mus musculus |
| 3 | These observations suggest that heterologous interactions between mGluRs and CB1Rs control the temporal window of DSI at GABA synapses, providing evidence for a powerful new way to affect functional circuit connectivity in the brain.SIGNIFICANCE STATEMENT Postsynaptic depolarization liberates endocannabinoids, resulting in a rapid and transient decrease in release probability at GABA synapses. | gamma-Aminobutyric Acid | cannabinoid receptor 1 (brain) | Mus musculus |