Pub. Date : 2018 Nov 6
PMID : 30352856
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The loss of BRCA1 caused marked increases of pathological TOP2ccs in G1 phase following exposure to etoposide, which generates pathological TOP2ccs. | Etoposide | BRCA1 DNA repair associated | Homo sapiens |
| 2 | BRCA1-deficient cells showed a decrease in etoposide-induced MRE11 foci in G1 phase, suggesting that BRCA1 repairs pathological TOP2ccs by promoting the recruitment of MRE11 to TOP2cc sites. | Etoposide | BRCA1 DNA repair associated | Homo sapiens |
| 3 | BRCA1-deficient cells showed a decrease in etoposide-induced MRE11 foci in G1 phase, suggesting that BRCA1 repairs pathological TOP2ccs by promoting the recruitment of MRE11 to TOP2cc sites. | Etoposide | BRCA1 DNA repair associated | Homo sapiens |
| 4 | BRCA1 thus plays a critical role in removing pathological TOP2ccs induced by estrogens as well as etoposide. | Etoposide | BRCA1 DNA repair associated | Homo sapiens |