Pub. Date : 2018 Nov 17
PMID : 30348524
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MiR-129-5p inhibits autophagy and apoptosis of H9c2 cells induced by hydrogen peroxide via the PI3K/AKT/mTOR signaling pathway by targeting ATG14. | Hydrogen Peroxide | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 2 | The present study was aimed to investigate the effect of miR-129-5p on the autophagy and apoptosis by targeting ATG14 as well as how miR-129-5p worked through the PI3K/AKT/mTOR signaling pathway in H2O2-induced H9c2 cells. | Hydrogen Peroxide | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 3 | Moreover, phosphorylation of PI3K/AKT/mTOR pathway was activated by miR-129-5p overexpression or ATG14 inhibition to alleviate the autophagy and apoptosis in H2O2-induced H9c2 cells. | Hydrogen Peroxide | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 4 | In conclusion, this study indicated that miR-129-5p inhibited autophagy and apoptosis in H2O2-induced H9c2 cells partly by down-regulation of ATG14 through the activation of PI3K/AKT/mTOR pathway. | Hydrogen Peroxide | AKT serine/threonine kinase 1 | Rattus norvegicus |