Pub. Date : 2018 Nov 15
PMID : 30340067
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Quantitative analysis of 4beta- and 4alpha-hydroxycholesterol in human plasma and serum by UHPLC/ESI-HR-MS. Cholesterol oxidation product 4beta-hydroxycholesterol (4beta-OHC) may possibly be used as an endogenous biomarker of CYP3A enzyme activity and as CYP3A4 is involved in the metabolism of approximately 50% of the drugs in clinical use, the monitoring of CYP3A activity by 4beta-OHC plasma or serum levels, may be of clinical significance. | cholest-5-ene-3,4-diol | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Quantitative analysis of 4beta- and 4alpha-hydroxycholesterol in human plasma and serum by UHPLC/ESI-HR-MS. Cholesterol oxidation product 4beta-hydroxycholesterol (4beta-OHC) may possibly be used as an endogenous biomarker of CYP3A enzyme activity and as CYP3A4 is involved in the metabolism of approximately 50% of the drugs in clinical use, the monitoring of CYP3A activity by 4beta-OHC plasma or serum levels, may be of clinical significance. | cholest-5-ene-3,4-diol | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Quantitative analysis of 4beta- and 4alpha-hydroxycholesterol in human plasma and serum by UHPLC/ESI-HR-MS. Cholesterol oxidation product 4beta-hydroxycholesterol (4beta-OHC) may possibly be used as an endogenous biomarker of CYP3A enzyme activity and as CYP3A4 is involved in the metabolism of approximately 50% of the drugs in clinical use, the monitoring of CYP3A activity by 4beta-OHC plasma or serum levels, may be of clinical significance. | cholest-5-ene-3,4-diol | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |