Pub. Date : 2018
PMID : 30337961
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Synergistic inhibition of MEK/ERK and BRAF V600E with PD98059 and PLX4032 induces sodium/iodide symporter (NIS) expression and radioiodine uptake in BRAF mutated papillary thyroid cancer cells. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Methods: BCPAP and K1 cells were exposed to increasing concentrations of BRAF V600E inhibitor PLX4032 (0.01 muM, 0.1 muM, 1 muM) or MEK/ERK inhibitor PD98059 (0.01 muM, 0.1 muM, 1 muM) or with their association or/and in the presence of 3 mM perchlorate (ClO- 4) for 0-72 h. Iodide uptake and expression of BRAF, phosphorylated (p) ERK1/2, NIS were detected. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | However, combined treatment of PLX4032 and PD98059 completely inhibited p-ERK expression. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | mitogen-activated protein kinase 1 | Homo sapiens |