Title : Effect of catechol estrogens on prolactin secretion in the rat: lack of correlation with estrogenic activity.

Pub. Date : 1987 Feb

PMID : 3033538






4 Functional Relationships(s)
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1 Temporal changes in plasma prolactin (PRL) levels caused by the administration of a number of different catechol estrogens to freely-moving conscious male rats were determined. catechol prolactin Rattus norvegicus
2 Temporal changes in plasma prolactin (PRL) levels caused by the administration of a number of different catechol estrogens to freely-moving conscious male rats were determined. catechol prolactin Rattus norvegicus
3 The effect on PRL secretion was found to be more pronounced when the catechol estrogens were administered to rats bearing implants of estradiol and could not be correlated with their Kd values for the estrogen receptor. catechol prolactin Rattus norvegicus
4 The experiments support the hypothesis that catechol estrogens generally act as short-term dopamine agonists, lowering PRL, but that those which possess estrogenic activity also show a more prolonged PRL-elevating effect. catechol prolactin Rattus norvegicus