Title : Insulin inhibition of hepatic cAMP-dependent protein kinase: decreased affinity of protein kinase for cAMP and possible differential regulation of intrachain sites 1 and 2.

Pub. Date : 1987 Apr

PMID : 3031673






1 Functional Relationships(s)
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1 In hepatocytes stimulated with 8-bromo-cAMP, insulin decreases the affinity of the cAMP-dependent protein kinase for cAMP, shifting the Ka without affecting the Vmax activity. 8-Bromo Cyclic Adenosine Monophosphate insulin Homo sapiens