Title : Structure-guided design of pyridoclax derivatives based on Noxa / Mcl-1 interaction mode.

Pub. Date : 2018 Nov 5

PMID : 30308410






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 This new derivative selectively binds to the Mcl-1 hydrophobic groove and releases Bak and Bim from Mcl-1 to induce cell death and sensitize cancer cells to Bcl-2/Bcl-xL targeting strategies. bakuchiol BCL2 like 1 Homo sapiens