Pub. Date : 2018 Oct 1
PMID : 30307162
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | After 2-day exposure to palmitate, OCR and the marker of the adaptive arm of ER stress response (sorcin) were significantly raised, whereas AMPK phosphorylation, markers of pro-apoptotic arm of ER stress response (p-EIF2alpha and CHOP) and apoptosis (cleaved caspase 3) were not affected. | Palmitates | DNA damage inducible transcript 3 | Homo sapiens |
| 2 | After 7-day exposure to palmitate, OCR and sorcin were not significantly different from control level, p-AMPK was reduced and p-EIF2alpha, CHOP and cleaved caspase 3 were strongly upregulated. | Palmitates | DNA damage inducible transcript 3 | Homo sapiens |
| 3 | Presence of metformin during 7-day culture with palmitate normalized the level of p-AMPK, p-EIF2alpha, CHOP and cleaved caspase 3 but significantly increased the level of sorcin. | Palmitates | DNA damage inducible transcript 3 | Homo sapiens |