Title : In vitro metabolism of etoposide (VP-16-213) by liver microsomes and irreversible binding of reactive intermediates to microsomal proteins.

Pub. Date : 1987 Feb 15

PMID : 3030329






1 Functional Relationships(s)
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1 The formation of DHVP-16 was cytochrome P-450-mediated as indicated by its dependence on NADPH, its increased production following treatment of mice with phenobarbital, and its marked inhibition by SKF-525A and piperonyl butoxide. Phenobarbital cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus