Title : Highly Diastereo- and Enantioselective Synthesis of Nitrile-Substituted Cyclopropanes by Myoglobin-Mediated Carbene Transfer Catalysis.

Pub. Date : 2018 Nov 26

PMID : 30300955






1 Functional Relationships(s)
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1 The present approach relies on an asymmetric olefin cyclopropanation reaction catalyzed by an engineered myoglobin in the presence of ex situ generated diazoacetonitrile within a compartmentalized reaction system. Alkenes myoglobin Homo sapiens