Title : Increasing the distance between two monomers of topoisomerase IIβ under the action of antitumor agent 4β-sulfur-(benzimidazole) 4'-demethylepipodophyllotoxin.

Pub. Date : 2018 Oct 8

PMID : 30297860






1 Functional Relationships(s)
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1 Through the comparison of the structures of hTop2beta-DNA-etoposide ternary complex and hTop2beta-DNA binary complex, it could be observed that the distance between drug-binding sites Arg503 of the two monomers was 26.62 A in hTop2beta-DNA-etoposide ternary complex and 34.54 A in hTop2beta-DNA binary complex, respectively. Etoposide DNA topoisomerase II beta Homo sapiens