Pub. Date : 2018 Dec 1
PMID : 30291937
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Andrographolide alone increased p62 and p-p62 (S349) but not LC3B-II in BEAS-2B cells. | andrographolide | nucleoporin 62 | Homo sapiens |
2 | However, in the presence of CSE, andrographolide was able to simultaneously increase LC3B-II level and enhance antioxidant defense by decreasing oxidative stress and increasing total antioxidant capacity, through upregulation of nuclear Nrf2 via the p62-Nrf2 positive feedback loop. | andrographolide | nucleoporin 62 | Homo sapiens |
3 | Our findings revealed for the first time that andrographolide simultaneously upregulated antioxidant defense through the p62-Nrf2 loop and moderately induced apoptosis through impairment of autophagic flux in CSE-exposed bronchial epithelium. | andrographolide | nucleoporin 62 | Homo sapiens |