Title : Andrographolide simultaneously augments Nrf2 antioxidant defense and facilitates autophagic flux blockade in cigarette smoke-exposed human bronchial epithelial cells.

Pub. Date : 2018 Dec 1

PMID : 30291937






3 Functional Relationships(s)
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1 Andrographolide alone increased p62 and p-p62 (S349) but not LC3B-II in BEAS-2B cells. andrographolide nucleoporin 62 Homo sapiens
2 However, in the presence of CSE, andrographolide was able to simultaneously increase LC3B-II level and enhance antioxidant defense by decreasing oxidative stress and increasing total antioxidant capacity, through upregulation of nuclear Nrf2 via the p62-Nrf2 positive feedback loop. andrographolide nucleoporin 62 Homo sapiens
3 Our findings revealed for the first time that andrographolide simultaneously upregulated antioxidant defense through the p62-Nrf2 loop and moderately induced apoptosis through impairment of autophagic flux in CSE-exposed bronchial epithelium. andrographolide nucleoporin 62 Homo sapiens