Pub. Date : 2018 Nov 20
PMID : 30285425
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Endocannabinoid Virodhamine Is an Endogenous Inhibitor of Human Cardiovascular CYP2J2 Epoxygenase. | virodhamine | cytochrome P450 family 2 subfamily J member 2 | Homo sapiens |
| 2 | Herein, using competitive binding studies, kinetic metabolism measurements, molecular dynamics, and wound healing assays, we have shown that O-AEA is an endogenous inhibitor of CYP2J2 epoxygenase. | virodhamine | cytochrome P450 family 2 subfamily J member 2 | Homo sapiens |
| 3 | As a result, the role of O-AEA as an endogenous eCB inhibitor of CYP2J2 may provide a new mode of regulation to control the activity of cardiovascular CYP2J2 in vivo and suggests a potential cross-talk between the cardiovascular endocannabinoids and the cytochrome P450 system. | virodhamine | cytochrome P450 family 2 subfamily J member 2 | Homo sapiens |
| 4 | As a result, the role of O-AEA as an endogenous eCB inhibitor of CYP2J2 may provide a new mode of regulation to control the activity of cardiovascular CYP2J2 in vivo and suggests a potential cross-talk between the cardiovascular endocannabinoids and the cytochrome P450 system. | virodhamine | cytochrome P450 family 2 subfamily J member 2 | Homo sapiens |