Pub. Date : 2018
PMID : 30283359
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lysophosphatidic Acid Is Associated With Cardiac Dysfunction and Hypertrophy by Suppressing Autophagy via the LPA3/AKT/mTOR Pathway. | lysophosphatidic acid | lysophosphatidic acid receptor 3 | Rattus norvegicus |
| 2 | In addition, we found that knockdown of LPA3 alleviated LPA-mediated autophagy suppression in H9C2 cardiomyoblasts, suggesting that LPA suppresses autophagy through activation of the LPA3 and AKT/mTOR pathways. | lysophosphatidic acid | lysophosphatidic acid receptor 3 | Rattus norvegicus |
| 3 | In addition, we found that knockdown of LPA3 alleviated LPA-mediated autophagy suppression in H9C2 cardiomyoblasts, suggesting that LPA suppresses autophagy through activation of the LPA3 and AKT/mTOR pathways. | lysophosphatidic acid | lysophosphatidic acid receptor 3 | Rattus norvegicus |
| 4 | In addition, we found that knockdown of LPA3 alleviated LPA-mediated autophagy suppression in H9C2 cardiomyoblasts, suggesting that LPA suppresses autophagy through activation of the LPA3 and AKT/mTOR pathways. | lysophosphatidic acid | lysophosphatidic acid receptor 3 | Rattus norvegicus |
| 5 | Conclusion: These findings suggest that LPA plays an important role in mediating cardiac dysfunction and hypertrophy after a MI, and that LPA suppresses autophagy through activation of the LPA3 and AKT/mTOR pathways to induce cardiomyocyte hypertrophy. | lysophosphatidic acid | lysophosphatidic acid receptor 3 | Rattus norvegicus |