Pub. Date : 2018 Nov
PMID : 30282607
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Proteomic analyses reveal GNG12 regulates cell growth and casein synthesis by activating the Leu-mediated mTORC1 signaling pathway. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 2 | Cell growth, casein synthesis and mTORC1 signaling pathway were decreased in response to Leu absence, but these decreases were partially restored by GNG12 overexpression, and those effects were partially reversed by inhibiting GNG12. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 3 | Taken together, these results suggest that GNG12 is a positive regulator of the Leu-mediated mTORC1 signaling pathway in CMECs that promotes cell growth and casein synthesis. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |