Title : Simvastatin ameliorates total liver ischemia/reperfusion injury via KLF2-mediated mechanism in rats.

Pub. Date : 2019 Apr

PMID : 30274910






1 Functional Relationships(s)
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1 Furthermore, simvastatin pretreatment affected superoxide dismutase and malondialdehyde activities (P < 0.05) to reduce oxidative stress, and inhibited levels of high-mobility group box-1, CD68, toll-like receptor 4, tumor necrosis factor alpha, interleukin-1beta and interleukin-6 (P < 0.05) to suppress inflammatory response. Simvastatin interleukin 6 Rattus norvegicus