Pub. Date : 2018 Dec
PMID : 30273598
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We first demonstrated that 7-ketocholesterol stimulated Nlrp3 inflammasome formation and activation as shown by increased colocalization of inflammasome components [Nlrp3 versus apoptosis associated speck-like protein (Asc) or caspase-1] and enhanced cleavage of caspase-1 into active caspase-1 to generate IL-1beta in coronary artery smooth muscle cells. | 7-ketocholesterol | NLR family, pyrin domain containing 3 | Mus musculus |
| 2 | We first demonstrated that 7-ketocholesterol stimulated Nlrp3 inflammasome formation and activation as shown by increased colocalization of inflammasome components [Nlrp3 versus apoptosis associated speck-like protein (Asc) or caspase-1] and enhanced cleavage of caspase-1 into active caspase-1 to generate IL-1beta in coronary artery smooth muscle cells. | 7-ketocholesterol | NLR family, pyrin domain containing 3 | Mus musculus |