Title : Modelling brain dopamine-serotonin vesicular transport disease in Caenorhabditis elegans.

Pub. Date : 2018 Nov 9

PMID : 30266839






2 Functional Relationships(s)
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1 Brain dopamine-serotonin vesicular transport disease is a rare disease caused by autosomal recessive mutations in the SLC18A2 gene, which encodes the VMAT2 protein. Serotonin solute carrier family 18 member A2 Homo sapiens
2 Investigations into dopamine- and serotonin-related C. elegans phenotypes, including pharyngeal pumping and grazing, showed that both mutations cause significant impairment of these processes when compared with a non-transgenic N2 strain and a transgenic containing the wild-type human SLC18A2 gene. Serotonin solute carrier family 18 member A2 Homo sapiens