Pub. Date : 2018 Sep 26
PMID : 30258081
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we identify niclosamide through a HTS screen for compounds selectively killing p53-deficient cells. | Niclosamide | tumor protein p53 | Homo sapiens |
| 2 | Niclosamide impairs the growth of p53-deficient cells and of p53 mutant patient-derived ovarian xenografts. | Niclosamide | tumor protein p53 | Homo sapiens |
| 3 | Niclosamide impairs the growth of p53-deficient cells and of p53 mutant patient-derived ovarian xenografts. | Niclosamide | tumor protein p53 | Homo sapiens |
| 4 | Metabolome profiling reveals that niclosamide induces mitochondrial uncoupling, which renders mutant p53 cells susceptible to mitochondrial-dependent apoptosis through preferential accumulation of arachidonic acid (AA), and represents a first-in-class inhibitor of p53 mutant tumors. | Niclosamide | tumor protein p53 | Homo sapiens |
| 5 | Metabolome profiling reveals that niclosamide induces mitochondrial uncoupling, which renders mutant p53 cells susceptible to mitochondrial-dependent apoptosis through preferential accumulation of arachidonic acid (AA), and represents a first-in-class inhibitor of p53 mutant tumors. | Niclosamide | tumor protein p53 | Homo sapiens |
| 6 | Therefore, we propose a new paradigm for targeting cancers defective in the p53 pathway, by exploiting their vulnerability to niclosamide-induced mitochondrial uncoupling. | Niclosamide | tumor protein p53 | Homo sapiens |