Pub. Date : 2018
PMID : 30254586
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | More importantly, by using SP600125, a selective Jnk inhibitor, we showed that Hes was able to significantly attenuate the Jnk downstream expression of Irf-3 and c-Jun, thereby inactivating NF-kappaB/MAPK signaling and transcriptional factor NFATc-1, leading to suppression of osteoclast-specific genes, which resulted in impaired osteoclastogenesis and functionality. | pyrazolanthrone | interferon regulatory factor 3 | Mus musculus |