Pub. Date : 2018 Oct 9
PMID : 30254161
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we show that Atg2 has two membrane-binding domains in the N- and C-terminal regions and acts as a membrane tether during autophagosome formation in the budding yeast Saccharomyces cerevisiae An amphipathic helix in the C-terminal region binds to membranes and facilitates Atg18 binding to PI3P to target the Atg2-Atg18 complex to the PAS. | Aminosalicylic Acid | Atg2p | Saccharomyces cerevisiae S288C |
| 2 | Based on these results, we propose that the Atg2-Atg18 complex tethers the PAS to the ER to initiate membrane expansion during autophagosome formation. | Aminosalicylic Acid | Atg2p | Saccharomyces cerevisiae S288C |