Title : cPLA2 and desaturases underlie the tau hyperphosphorylation offset induced by BACE knock-down in neuronal primary cultures.

Pub. Date : 2018 Nov

PMID : 30251689






2 Functional Relationships(s)
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1 In this study, we analyze the role of cPLA2 and desaturases (SCD1, FAD6) in the BACE1 knockdown-induced protective action under a glutamate excitotoxicity model. Glutamic Acid beta-secretase 1 Homo sapiens
2 Glutamate (125 muM) produced hyperphosphorylation of tau in cortical primary cultures along with increased apoptotic nuclei, LDH release, and cPLA2 expression, which were all reversed by BACE1-KD. Glutamic Acid beta-secretase 1 Homo sapiens