Pub. Date : 2019 Jul
PMID : 30249767
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Elastin modulation and modification by homocysteine: a key factor in the pathogenesis of Pseudoexfoliation syndrome? | Homocysteine | elastin | Homo sapiens |
| 2 | Hcy (200 microM) and HCTL (1 microM) promoted elastin expression at mRNA level by 36-fold (p=0.02) and 10-fold (p=0.05), respectively, and at protein level by nearly two-fold in cultured hLECs. | Homocysteine | elastin | Homo sapiens |
| 3 | CONCLUSION: The study reveals that lens accumulation of Hcy associated with hyperhomocysteinaemia is characteristic of PXF that augments elastin expression. | Homocysteine | elastin | Homo sapiens |
| 4 | Hcy causes structural changes promoting elastin aggregation, thereby contributing to defective elastin in PXF and PXF-G. | Homocysteine | elastin | Homo sapiens |
| 5 | Hcy causes structural changes promoting elastin aggregation, thereby contributing to defective elastin in PXF and PXF-G. | Homocysteine | elastin | Homo sapiens |