Pub. Date : 2018 Dec
PMID : 30245469
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Melatonin improves vascular cognitive impairment induced by ischemic stroke by remyelination via activation of ERK1/2 signaling and restoration of glutamatergic synapses in the gerbil hippocampus. | Melatonin | mitogen-activated protein kinase 3 | Homo sapiens |
| 2 | In addition, melatonin treatment significantly increased ERK1/2 and p-ERK1/2 immunoreactivities in oligodendrocytes in the ischemic CA1. | Melatonin | mitogen-activated protein kinase 3 | Homo sapiens |
| 3 | In addition, melatonin treatment significantly increased ERK1/2 and p-ERK1/2 immunoreactivities in oligodendrocytes in the ischemic CA1. | Melatonin | mitogen-activated protein kinase 3 | Homo sapiens |
| 4 | These results indicate that long-term melatonin treatment after tGCI improves cognitive deficit via restoration of myelin, increase of oligodendrocytes which is closely related to the activation of ERK1/2 signaling, and increase of glutamatergic synapses in the ischemic brain area. | Melatonin | mitogen-activated protein kinase 3 | Homo sapiens |