Pub. Date : 2018 Nov
PMID : 30245128
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Iron attenuates erythropoietin production by decreasing hypoxia-inducible transcription factor 2alpha concentrations in renal interstitial fibroblasts. | Iron | erythropoietin | Mus musculus |
| 2 | Because iron is primarily used in red blood cells, defective erythropoiesis caused by loss of the erythroid growth factor erythropoietin (Epo) elevates iron storage levels in serum and tissues. | Iron | erythropoietin | Mus musculus |
| 3 | Because iron is primarily used in red blood cells, defective erythropoiesis caused by loss of the erythroid growth factor erythropoietin (Epo) elevates iron storage levels in serum and tissues. | Iron | erythropoietin | Mus musculus |
| 4 | Because iron is primarily used in red blood cells, defective erythropoiesis caused by loss of the erythroid growth factor erythropoietin (Epo) elevates iron storage levels in serum and tissues. | Iron | erythropoietin | Mus musculus |
| 5 | Because iron is primarily used in red blood cells, defective erythropoiesis caused by loss of the erythroid growth factor erythropoietin (Epo) elevates iron storage levels in serum and tissues. | Iron | erythropoietin | Mus musculus |
| 6 | We found that intraperitoneal injection of iron-dextran caused severe iron deposition in renal interstitial fibroblasts, the site of Epo production. | Iron | erythropoietin | Mus musculus |
| 7 | Iron overload induced by either intraperitoneal injection or feeding decreased activity of endogenous Epo gene expression by reducing levels of hypoxia-inducible transcription factor 2alpha (HIF2alpha), the major transcriptional activator of the Epo gene. | Iron | erythropoietin | Mus musculus |
| 8 | Iron overload induced by either intraperitoneal injection or feeding decreased activity of endogenous Epo gene expression by reducing levels of hypoxia-inducible transcription factor 2alpha (HIF2alpha), the major transcriptional activator of the Epo gene. | Iron | erythropoietin | Mus musculus |
| 9 | Administration of an iron-deficient diet to the anemic mice reduced serum iron to normal concentration and enhanced the ability of renal Epo production. | Iron | erythropoietin | Mus musculus |
| 10 | These results demonstrate that iron overload due to Epo deficiency attenuates endogenous Epo gene expression in the kidneys. | Iron | erythropoietin | Mus musculus |
| 11 | These results demonstrate that iron overload due to Epo deficiency attenuates endogenous Epo gene expression in the kidneys. | Iron | erythropoietin | Mus musculus |
| 12 | Thus, iron suppresses Epo production by reducing HIF2alpha concentration in renal interstitial fibroblasts. | Iron | erythropoietin | Mus musculus |