Pub. Date : 2019 Mar
PMID : 30237268
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Transglutaminase 2 programs differentiating acute promyelocytic leukemia cells in all-trans retinoic acid treatment to inflammatory stage through NF-kappaB activation. | Tretinoin | transglutaminase 2 | Homo sapiens |
| 2 | Administration of all-trans retinoic acid leads to significant changes in gene expression, among the most induced of which is transglutaminase 2, which is not normally expressed in neutrophil granulocytes. | Tretinoin | transglutaminase 2 | Homo sapiens |
| 3 | This study demonstrates that transglutaminase 2 expression induced by all-trans retinoic acid treatment reprograms inflammatory signaling networks governed by nuclear factor kappa-light-chain-enhancer of activated B-cell activation, resulting in overexpression of TNF-alpha and IL-1beta in differentiating APL cells, suggesting that atypically expressed transglutaminase 2 is a promising target for leukemia treatment. | Tretinoin | transglutaminase 2 | Homo sapiens |
| 4 | This study demonstrates that transglutaminase 2 expression induced by all-trans retinoic acid treatment reprograms inflammatory signaling networks governed by nuclear factor kappa-light-chain-enhancer of activated B-cell activation, resulting in overexpression of TNF-alpha and IL-1beta in differentiating APL cells, suggesting that atypically expressed transglutaminase 2 is a promising target for leukemia treatment. | Tretinoin | transglutaminase 2 | Homo sapiens |