Title : 1,25(OH)2D3 and dexamethasone additively suppress synovial fibroblast activation by CCR6+ T helper memory cells and enhance the effect of tumor necrosis factor alpha blockade.

Pub. Date : 2018 Sep 20

PMID : 30236152






4 Functional Relationships(s)
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1 1,25(OH)2D3 and dexamethasone additively suppress synovial fibroblast activation by CCR6+ T helper memory cells and enhance the effect of tumor necrosis factor alpha blockade. Calcitriol tumor necrosis factor Homo sapiens
2 Tumor necrosis factor (TNF)alpha was only inhibited by the combination of 1,25(OH)2D3 and DEX. Calcitriol tumor necrosis factor Homo sapiens
3 Tumor necrosis factor (TNF)alpha was only inhibited by the combination of 1,25(OH)2D3 and DEX. Calcitriol tumor necrosis factor Homo sapiens
4 Furthermore, low doses of DEX and 1,25(OH)2D3 enhance the effect of TNFalpha blockade in inhibiting RASF activation, thus providing a basis to improve RA treatment. Calcitriol tumor necrosis factor Homo sapiens