Pub. Date : 2018 Dec
PMID : 30232176
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Calcitriol and Calcipotriol Modulate Transport Activity of ABC Transporters and Exhibit Selective Cytotoxicity in MRP1-overexpressing Cells. | Calcitriol | ATP binding cassette subfamily C member 1 | Homo sapiens |
| 2 | We report that the active metabolite of vitamin D3, calcitriol, and its analog calcipotriol are selectively cytotoxic to MRP1-overexpressing cells, besides inhibiting transport function of P-gp, MRP1, and BCRP. | Calcitriol | ATP binding cassette subfamily C member 1 | Homo sapiens |
| 3 | We report that the active metabolite of vitamin D3, calcitriol, and its analog calcipotriol are selectively cytotoxic to MRP1-overexpressing cells, besides inhibiting transport function of P-gp, MRP1, and BCRP. | Calcitriol | ATP binding cassette subfamily C member 1 | Homo sapiens |
| 4 | Calcitriol and calcipotriol consistently displayed a potent inhibitory activity on MRP1-mediated doxorubicin and calcein efflux in MRP1-overexpressing H69AR and HEK293/MRP1 cells. | Calcitriol | ATP binding cassette subfamily C member 1 | Homo sapiens |
| 5 | Calcitriol and calcipotriol consistently displayed a potent inhibitory activity on MRP1-mediated doxorubicin and calcein efflux in MRP1-overexpressing H69AR and HEK293/MRP1 cells. | Calcitriol | ATP binding cassette subfamily C member 1 | Homo sapiens |
| 6 | Calcitriol and calcipotriol consistently displayed a potent inhibitory activity on MRP1-mediated doxorubicin and calcein efflux in MRP1-overexpressing H69AR and HEK293/MRP1 cells. | Calcitriol | ATP binding cassette subfamily C member 1 | Homo sapiens |
| 7 | Vesicular transport studies confirmed a strong inhibitory effect of calcitriol and calcipotriol on MRP1-mediated uptake of tritium-labeled estradiol glucuronide and leukotriene C4 In cytotoxicity assays, MRP1-overexpressing cells exhibited hypersensitivity toward calcitriol and calcipotriol. | Calcitriol | ATP binding cassette subfamily C member 1 | Homo sapiens |
| 8 | Vesicular transport studies confirmed a strong inhibitory effect of calcitriol and calcipotriol on MRP1-mediated uptake of tritium-labeled estradiol glucuronide and leukotriene C4 In cytotoxicity assays, MRP1-overexpressing cells exhibited hypersensitivity toward calcitriol and calcipotriol. | Calcitriol | ATP binding cassette subfamily C member 1 | Homo sapiens |
| 9 | Vesicular transport studies confirmed a strong inhibitory effect of calcitriol and calcipotriol on MRP1-mediated uptake of tritium-labeled estradiol glucuronide and leukotriene C4 In cytotoxicity assays, MRP1-overexpressing cells exhibited hypersensitivity toward calcitriol and calcipotriol. | Calcitriol | ATP binding cassette subfamily C member 1 | Homo sapiens |
| 10 | The selective cytotoxicity of calcitriol and calpotriol toward MRP1 over-expressing cells can be eliminated with MRP1 inhibitor MK571. | Calcitriol | ATP binding cassette subfamily C member 1 | Homo sapiens |
| 11 | The selective cytotoxicity of calcitriol and calpotriol toward MRP1 over-expressing cells can be eliminated with MRP1 inhibitor MK571. | Calcitriol | ATP binding cassette subfamily C member 1 | Homo sapiens |
| 12 | Our data indicate a potential role of calcitriol and its analogs in targeting malignancies in which MRP1 expression is prominent and contributes to MDR. | Calcitriol | ATP binding cassette subfamily C member 1 | Homo sapiens |