Title : Complement 1q-like-3 protein inhibits insulin secretion from pancreatic β-cells via the cell adhesion G protein-coupled receptor BAI3.

Pub. Date : 2018 Nov 23

PMID : 30228187






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 We found that C1ql3 predominantly inhibits exendin-4- and cAMP-stimulated insulin secretion from mouse and human islets. Cyclic AMP insulin Homo sapiens
2 These results suggest that C1ql3 inhibits insulin secretion primarily by regulating cAMP signaling. Cyclic AMP insulin Homo sapiens
3 Furthermore, incubating the soluble C1ql3-binding fragment of the BAI3 protein completely blocked the inhibitory effects of C1ql3 on insulin secretion in response to cAMP. Cyclic AMP insulin Homo sapiens