Title : c-Myc Is a Major Determinant for Antitumor Activity of Aurora A Kinase Inhibitor MLN8237 in Thyroid Cancer.

Pub. Date : 2018 Dec

PMID : 30226440






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1 METHODS: The phenotypic effects of MLN8237 in thyroid cancer cells were evaluated through a series of in vitro and in vivo experiments, and the mechanism of c-Myc affecting MLN8237 response were explored using Western blot, ubiquitination, and cycloheximide chase assays. Cycloheximide MYC proto-oncogene, bHLH transcription factor Homo sapiens