Title : Immunomodulatory and anti-inflammatory effects of total flavonoids of Astragalus by regulating NF-ΚB and MAPK signalling pathways in RAW 264.7 macrophages.

Pub. Date : 2018 Oct 1

PMID : 30223923






3 Functional Relationships(s)
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1 Further studies revealed that TFA significantly inhibited iNOS and COX-2 protein levels, the phosphorylations of p38 and JNK in MAPKs pathway and IKKalpha/beta, IkappaBalpha and the expression of nuclear NF-kappaB p65 in NF-kappaB pathway in LPS-stimulated RAW 264.7 cells. Trifluoroacetic Acid nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
2 Further studies revealed that TFA significantly inhibited iNOS and COX-2 protein levels, the phosphorylations of p38 and JNK in MAPKs pathway and IKKalpha/beta, IkappaBalpha and the expression of nuclear NF-kappaB p65 in NF-kappaB pathway in LPS-stimulated RAW 264.7 cells. Trifluoroacetic Acid nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
3 It suggests that TFA possesses immunomodulatory and anti-inflammatory effects by regulating MAPK and NF-KappaB signalling pathways in RAW 264.7 macrophages. Trifluoroacetic Acid nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus