Title : Combination of pristimerin and paclitaxel additively induces autophagy in human breast cancer cells via ERK1/2 regulation.

Pub. Date : 2018 Nov

PMID : 30221728






3 Functional Relationships(s)
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1 Treatment with pristimerin dose-dependently induced an increase of light chain 3B (LC3-II), whereas autophagy inhibitor 3-methyladenine (3-MA) inhibited pristimerin-induced LC3-II accumulation and cytotoxic effects. 3-methyladenine microtubule associated protein 1 light chain 3 alpha Homo sapiens
2 Treatment with pristimerin dose-dependently induced an increase of light chain 3B (LC3-II), whereas autophagy inhibitor 3-methyladenine (3-MA) inhibited pristimerin-induced LC3-II accumulation and cytotoxic effects. 3-methyladenine microtubule associated protein 1 light chain 3 alpha Homo sapiens
3 Treatment with 3-MA inhibited LC3-II accumulation and cell death induced by a combination of paclitaxel and pristimerin. 3-methyladenine microtubule associated protein 1 light chain 3 alpha Homo sapiens