Pub. Date : 2018 Nov
PMID : 30221728
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pristimerin and paclitaxel inhibited extracellular signal-regulated kinase (ERK)1/2/p90RSK signaling, consistent with autophagy indicators, namely p62 degradation and beclin 1 expression. | Paclitaxel | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | In addition, ERK activator ceramide C6 treatment suppressed the LC3-II levels induced by a combination of paclitaxel and pristimerin. | Paclitaxel | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | These results suggested that exposure to pristimerin induced autophagic cell death, whereas a combination treatment of pristimerin and paclitaxel resulted in an additive effect on ERK-dependent autophagic cell death. | Paclitaxel | mitogen-activated protein kinase 1 | Homo sapiens |