Title : Oral administration of the casein kinase 2 inhibitor TBB leads to persistent KCa2.2 channel up-regulation in the epileptic CA1 area and cortex, but lacks anti-seizure efficacy in the pilocarpine epilepsy model.

Pub. Date : 2018 Nov

PMID : 30219695






2 Functional Relationships(s)
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1 Oral administration of the casein kinase 2 inhibitor TBB leads to persistent KCa2.2 channel up-regulation in the epileptic CA1 area and cortex, but lacks anti-seizure efficacy in the pilocarpine epilepsy model. 2-ethylhexyl 2,3,4,5-tetrabromobenzoate carbonic anhydrase 1 Rattus norvegicus
2 Hence, our findings indicate that oral administration of TBB leads to persistent up-regulation of KCa2.2 in the epileptic CA1 subfield and in the neocortex, but lacks anti-seizure efficacy in the pilocarpine epilepsy model. 2-ethylhexyl 2,3,4,5-tetrabromobenzoate carbonic anhydrase 1 Rattus norvegicus