Pub. Date : 2018 Nov 2
PMID : 30217824
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We identified c-Jun N-terminal kinase (JNK) as a key intermediary in mSin1 up-regulation by the pro-fibrotic mediators, as pharmacological and siRNA-mediated inhibition of JNK prevented the LPA-induced mSin1 increase. | lysophosphatidic acid | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | We identified c-Jun N-terminal kinase (JNK) as a key intermediary in mSin1 up-regulation by the pro-fibrotic mediators, as pharmacological and siRNA-mediated inhibition of JNK prevented the LPA-induced mSin1 increase. | lysophosphatidic acid | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | We identified c-Jun N-terminal kinase (JNK) as a key intermediary in mSin1 up-regulation by the pro-fibrotic mediators, as pharmacological and siRNA-mediated inhibition of JNK prevented the LPA-induced mSin1 increase. | lysophosphatidic acid | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | Proteasomal inhibition rescued mSin1 levels after JNK inhibition in LPA-treated MCs, and the decrease in mSin1 ubiquitination in response to LPA was counteracted by JNK inhibitors. | lysophosphatidic acid | mitogen-activated protein kinase 8 | Homo sapiens |